Beyond Structure - Solving Conformational Dynamics for Intractable Proteins

Monitoring structural change and drug release of responsive nanoparticles using polarity-sensitive fluorophores

Y Gao, PW McDonald, C Ritchie, GK Such

2025-12-28

Stimuli-responsive polymeric nanoparticles hold significant promise for enhancing the delivery of therapeutic agents, particularly..

Planarisation or a twist? Using steric engineering to unlock the origin of mechanofluorochromic red-shifts

PW McDonald, L Goerigk, C Ritchie

2025-08-27

Engineering the ground-state orientations of donor and acceptor groups through steric control of fluorophore conformations is an e..

Spin-scaled double hybrids with long-range correction solve the TD-DFT overestimation problem in BODIPY dyes: benchmarking and experimental validation

S Sebastian, V Riley, B Wanniarachchi, C Ritchie, L Goerigk

2025-06-30

It has been established in the literature that time-dependent density functional theory (TD-DFT) methods systematically overestima..

Fluorescence modulation of pyridinium betaines: a mechanofluorochromic investigation

PW McDonald, J Xu, DR Lonsdale, I Jones, B Poggi, RP Cox, S Aloise, AD Scully, C Allain, L Bodelot, SA Moggach, TDM Bell, R Métivier, SGB Furness, L Goerigk, C Ritchie

2024-12-04

A reversible change in a material's fluorescence spectrum on the application of force is known as mechanofluorochromism (MFC) and ..